UP Professor Finds Genetic Links to Heart Disease & Diabetes

UP Professor Uncovers Genetic Links To The Risk Of Heart Disease And Diabetes In South Africa

While cardiovascular disease and Type 2 diabetes surge in South Africa, the genetic underpinnings of these conditions within the country’s diverse populations remain largely unexplored. Professor Alisa Phulukdaree’s groundbreaking work at the University of Pretoria is changing that!

Many of us may know a loved one affected by Cardiovascular disease and Type 2 diabetes. These two health challenges have become two of South Africa’s most pressing and prevalent ones. Yet, much of the global research that informs treatment and prevention strategies has been conducted in populations that don’t reflect our genetic diversity.

This is according to the University of Pretoria’s (UP), Professor Alisa Phulukdaree from the Department of Physiology who shed light on the genetic and epigenetic factors influencing these diseases, particularly focusing on their impact in South Africa.

Her work not only explores why some population groups are more vulnerable to these conditions but also points to the potential for personalised medicine, an approach that could allow people to make informed health choices based on their genetic predisposition.

 “We know that heart disease and diabetes are on the rise in South Africa, but the genetic factors driving these conditions in our population remain largely understudied,” says Prof Phulukdaree.

“By uncovering how genetic and environmental factors interact, we can develop more precise strategies for prevention, early detection and treatment.”

The hidden genetic triggers of disease

In recent decades heart disease has become one of the leading causes of death in South Africa. Similarly, Type 2 diabetes, often linked to lifestyle factors, is rising sharply.

But what if the risk is written into one’s DNA? This is a key question posed by Prof Phulukdaree’s research which delves into how genetic variations and environmental factors interact to influence the development of coronary artery disease (CAD) and diabetes.

She studies genetic markers that regulate oxidative stress, inflammation and blood clotting – all of which contribute to the progression of these conditions.

Her findings are particularly relevant to South Africa’s Indian population, who experience significantly higher rates of CAD.

Read the full article on: Good Things Guy